Glucose and fatty acids synergistically and reversibly promote beta cell proliferation in rats.

ABSTRACT:

Aims/hypothesis

The mechanisms underlying pancreatic islet mass expansion have attracted considerable interest as potential therapeutic targets to prevent or delay the onset of type 2 diabetes. While several factors promoting beta cell proliferation have been identified, in the context of nutrient excess the roles of glucose or NEFA in relation to insulin resistance remain unclear. Here we tested the hypothesis that glucose and NEFA synergistically and reversibly promote beta cell proliferation in the context of nutrient-induced insulin resistance.

Methods

Using 72 h infusions of glucose (GLU) or the oleate-enriched lipid emulsion ClinOleic (CLI), singly or in combination, we assessed beta cell proliferation, islet mass and insulin sensitivity in male Lewis rats. The effects

SUBMITTER: Moulle VS 

PROVIDER: S-EPMC5376373 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature