Recovery of Serum Cholesterol Predicts Survival After Left Ventricular Assist Device Implantation.

ABSTRACT:

Background

Advanced systolic heart failure is associated with myocardial and systemic metabolic abnormalities, including low levels of total cholesterol and low-density lipoprotein. Low cholesterol and low-density lipoprotein have been associated with greater mortality in heart failure. Implantation of a left ventricular assist device (LVAD) reverses some of the metabolic derangements of advanced heart failure.

Methods and results

A cohort was retrospectively assembled from 2 high-volume implantation centers, totaling 295 continuous-flow LVAD recipients with ≥2 cholesterol values available. The cohort was predominantly bridge-to-transplantation (67%), with median age of 59 years and 49% ischemic heart failure cause. Total cholesterol, low-density lipoprotein, high-density li

SUBMITTER: Vest AR 

PROVIDER: S-EPMC5376501 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature