The Longitudinal Idiopathic Intracranial Hypertension Trial: Outcomes From Months 6-12.

ABSTRACT:

Purpose

To determine whether the beneficial effects of acetazolamide (ACZ) in improving vision at 6 months continues to month 12 in participants of the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT).

Design

Nonrandomized clinical study.

Methods

In the IIHTT, subjects were randomly assigned to placebo-plus-diet or maximally tolerated dosage of acetazolamide-plus-diet. At 6 months subjects transitioned from study drug to ACZ. This resulted in the following groups: (1) ACZ to ACZ; n = 34; (2) placebo to ACZ; n = 35; (3) ACZ to no treatment; n = 16; and (4) placebo to no treatment; n = 11. Ninety-six IIHTT subjects had evaluations at 6 and 12 months. Our main outcome measure was change from month 6 to month 12 in visual field mean deviation (MD) with seconda

SUBMITTER: Wall M 

PROVIDER: S-EPMC5376520 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature