Apolipoprotein E mimetic peptide, CN-105, improves outcomes in ischemic stroke.

ABSTRACT:

Objective

At present, the absence of a pharmacological neuroprotectant represents an important unmet clinical need in the treatment of ischemic and traumatic brain injury. Recent evidence suggests that administration of apolipoprotein E mimetic therapies represent a viable therapeutic strategy in this setting. We investigate the neuroprotective and anti-inflammatory properties of the apolipoprotein E mimetic pentapeptide, CN-105, in a microglial cell line and murine model of ischemic stroke.

Methods

Ten to 13-week-old male C57/BL6 mice underwent transient middle cerebral artery occlusion and were randomly selected to receive CN-105 (0.1 mg/kg) in 100 μL volume or vehicle via tail vein injection at various time points. Survival, motor-sensory functional outcomes using

SUBMITTER: Tu TM 

PROVIDER: S-EPMC5376751 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature