A Klebsiella pneumoniae antibiotic resistance mechanism that subdues host defences and promotes virulence.

ABSTRACT: Klebsiella pneumoniae is an important cause of multidrug-resistant infections worldwide. Recent studies highlight the emergence of multidrug-resistant K. pneumoniae strains which show resistance to colistin, a last-line antibiotic, arising from mutational inactivation of the mgrB regulatory gene. However, the precise molecular resistance mechanisms of mgrB-associated colistin resistance and its impact on virulence remain unclear. Here, we constructed an mgrB gene K. pneumoniae mutant and performed characterisation of its lipid A structure, polymyxin and antimicrobial peptide resistance, virulence and inflammatory responses upon infection. Our data reveal that mgrB mutation induces PhoPQ-governed lipid A remodelling which confers not only res

SUBMITTER: Kidd TJ 

PROVIDER: S-EPMC5376759 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature