Gender specific hippocampal whole genome transcriptome data from mice lacking the Ca_v2.3 R-type or Ca_v3.2 T-type voltage-gated calcium channel.

ABSTRACT: Voltage-gated Ca²⁺ channels are of central relevance in mediating numerous intracellular and transcellular processes including excitation-contraction coupling, excitation secretion-coupling, hormone and neurotransmitter release and gene expression. The Ca_v2.3 R-type Ca²⁺ channel is a high-voltage activated channel which plays a crucial role in neurotransmitter release, long-term potentiation and hormone release. Furthermore, Ca_v2.3 R-type channels were reported to be involved in ictogenesis, epileptogenesis, fear behavior, sleep, pre-and postsynaptic integration and rhythmicity within the hippocampus. Ca_v3 T-type Ca²⁺ channels are low-voltage activated and also widely expressed throughout the brain enabling neurons to switch

SUBMITTER: Papazoglou A 

PROVIDER: S-EPMC5376951 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature