HBV Viral Load and Liver Enzyme Levels May Be Associated with the Wild MBL2 AA Genotype.

ABSTRACT: The present study investigated the frequencies of rs1800450 (MBL ^⁎B, G>A), rs1800451 (MBL ^⁎C, G>A), and rs5030737 (MBL ^⁎D, C>T) polymorphisms in exon 1 of the MBL2 gene among patients with chronic viral hepatitis. Blood samples from patients infected with hepatitis B virus (HBV; n = 65), hepatitis C virus (HCV; n = 92), and a noninfected control group (n = 300) were investigated. The presence of polymorphisms was detected using a real-time polymerase chain reaction to correlate with liver disease pathogenesis and fibrosis staging according to the Metavir classification. The genotypic and allelic frequencies showed no significant differences between the groups, but patients with active HBV and the wild AA</

SUBMITTER: Moura TC 

PROVIDER: S-EPMC5376955 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature