Controlling T-Cell Activation with Synthetic Dendritic Cells Using the Multivalency Effect.

ABSTRACT: Artificial antigen-presenting cells (aAPCs) have recently gained a lot of attention. They efficiently activate T cells and serve as powerful replacements for dendritic cells in cancer immunotherapy. Focusing on a specific class of polymer-based aAPCs, so-called synthetic dendritic cells (sDCs), we have investigated the importance of multivalent binding on T-cell activation. Using antibody-functionalized sDCs, we have tested the influence of polymer length and antibody density. Increasing the multivalent character of the antibody-functionalized polymer lowered the effective concentration required for T-cell activation. This was evidenced for both early and late stages of activation. The most important effect observed was the significantly prolonged activation of the stimulated T cells, indi

SUBMITTER: Hammink R 

PROVIDER: S-EPMC5377267 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature