Doxorubicin inhibits muscle inflammation after eccentric exercise.

ABSTRACT:

Background

Doxorubicin, a widely used anti-tumour drug, is known to cause muscle loss in cancer patients.

Methods

Following an acute dose of doxorubicin injection (2.5 mg/kg per body weight), we examined macrophage distribution in rat soleus muscle challenged by eccentric exercise (downhill running). Long-term doxorubicin treatment (one injection every 3 days) on muscle mass and survival were also determined.

Results

Under non-exercised condition, increased tumour necrosis factor (TNF)-alpha mRNA and decreased IL-10 mRNA were observed in soleus muscle of doxorubicin-treated rats, compared with saline-treated control rats. However, increases in inflammation score (leukocyte infiltration), nitrotyrosine level, and M1 macrophage (CD68⁺ ) invasion in exercised

SUBMITTER: Huang SC 

PROVIDER: S-EPMC5377412 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature