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Cysteine persulfides and polysulfides produced by exchange reactions with H₂S protect SH-SY5Y cells from methylglyoxal-induced toxicity through Nrf2 activation.

ABSTRACT: Many physiological functions of hydrogen sulfide (H₂S) have been reported in mammalian cells over the last 20 years. These physiological effects have been ascertained through in vitro treatment of cells with Na₂S or NaHS, both of which are precursors of H₂S. Since H₂S exists as HS^- in a neutral solution, a disulfide compound such as cystine could react with HS^- in culture medium as well as in the cell. This study demonstrated that after the addition of Na₂S solution into culture medium, HS^- was transiently generated and disappeared immediately through the reaction between HS^- and cystine to form cysteine persulfides and polysulfides in the culture medium (bound sulfur mixture: BS-Mix). Furthe

SUBMITTER: Koike S

PROVIDER: S-EPMC5377440 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Cysteine persulfides and polysulfides produced by exchange reactions with H₂S protect SH-SY5Y cells from methylglyoxal-induced toxicity through Nrf2 activation.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Cysteine persulfides and polysulfides produced by exchange reactions with H2S protect SH-SY5Y cells from methylglyoxal-induced toxicity through Nrf2 activation.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Cysteine persulfides and polysulfides produced by exchange reactions with H₂S protect SH-SY5Y cells from methylglyoxal-induced toxicity through Nrf2 activation.