Multiplexed MRI methods for rapid estimation of global cerebral metabolic rate of oxygen consumption.

ABSTRACT: The global cerebral metabolic rate of oxygen (CMRO₂), which reflects metabolic activity of the brain under various physiologic conditions, can be quantified using a method, referred to as 'OxFlow', which simultaneously measures hemoglobin oxygen saturation in a draining vein (Y_v) and total cerebral blood flow (tCBF). Conventional OxFlow (Conv-OxFlow) entails four interleaves incorporated in a single pulse sequence - two for phase-contrast based measurement of tCBF in the supplying arteries of the neck, and two to measure the intra- to extravascular phase difference in the superior sagittal sinus to derive Y_v [Jain et al., JCBFM 2010]. However, this approach limits achievable temporal resolution thus precluding capture of rapid changes of brain metabolic sta

SUBMITTER: Lee H 

PROVIDER: S-EPMC5377447 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature