Entire CD3ε, δ, and γ humanized mouse to evaluate human CD3-mediated therapeutics.

ABSTRACT: T cell-mediated immunotherapy is an attractive strategy for treatment in various disease areas. In this therapeutic approach, the CD3 complex is one of the key molecules to modulate T cell functions; however, in many cases, we cannot evaluate the drug candidates in animal experiments because the therapeutics, usually monoclonal antibodies specific to human CD3, cannot react to mouse endogenous Cd3. Although immunodeficient mice transfused with human hematopoietic stem or precursor cells, known as humanized mice, are available for these studies, mice humanized in this manner are not completely immune competent. In this study we have succeeded in establishing a novel mouse strain in which all the three components of the Cd3 complex - Cd3ε, Cd3δ, and Cd3γ - are replaced by their human counter

SUBMITTER: Ueda O 

PROVIDER: S-EPMC5377452 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature