Detection of Antigenic Variants of Subtype H3 Swine Influenza A Viruses from Clinical Samples.

ABSTRACT: A large population of genetically and antigenically diverse influenza A viruses (IAVs) are circulating among the swine population, playing an important role in influenza ecology. Swine IAVs not only cause outbreaks among swine but also can be transmitted to humans, causing sporadic infections and even pandemic outbreaks. Antigenic characterizations of swine IAVs are key to understanding the natural history of these viruses in swine and to selecting strains for effective vaccines. However, influenza outbreaks generally spread rapidly among swine, and the conventional methods for antigenic characterization require virus propagation, a time-consuming process that can significantly reduce the effectiveness of vaccination programs. We developed and validated a rapid, sensitive, and robust metho

SUBMITTER: Martin BE 

PROVIDER: S-EPMC5377830 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature