Genomic Rearrangements in <i>Arabidopsis</i> Considered as Quantitative Traits.

ABSTRACT: To understand the population genetics of structural variants and their effects on phenotypes, we developed an approach to mapping structural variants that segregate in a population sequenced at low coverage. We avoid calling structural variants directly. Instead, the evidence for a potential structural variant at a locus is indicated by variation in the counts of short-reads that map anomalously to that locus. These structural variant traits are treated as quantitative traits and mapped genetically, analogously to a gene expression study. Association between a structural variant trait at one locus, and genotypes at a distant locus indicate the origin and target of a transposition. Using ultra-low-coverage (0.3×) population sequence data from 488 recombinant inbred Arabidopsis thaliana</

SUBMITTER: Imprialou M 

PROVIDER: S-EPMC5378104 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature