Pan-cancer analysis distinguishes transcriptional changes of aneuploidy from proliferation.

ABSTRACT: Patterns of gene expression in tumors can arise as a consequence of or result in genomic instability, characterized by the accumulation of somatic copy number alterations (SCNAs) and point mutations (PMs). Expression signatures have been widely used as markers for genomic instability, and both SCNAs and PMs could be thought to associate with distinct signatures given their different formation mechanisms. Here we test this notion by systematically investigating SCNA, PM, and transcriptome data from 2660 cancer patients representing 11 tumor types. Notably, our data indicate that similar expression signatures can be derived from correlating gene expression with either SCNA or PM load. Gene sets related to cell growth and proliferation generally associated positively, and immunoregulatory gen

SUBMITTER: Buccitelli C 

PROVIDER: S-EPMC5378169 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature