Quantification of intrapancreatic fat in type 2 diabetes by MRI.

ABSTRACT:

Objectives

Accumulation of intrapancreatic fat may be important in type 2 diabetes, but widely varying data have been reported. The standard quantification by MRI in vivo is time consuming and dependent upon a high level of experience. We aimed to develop a new method which would minimise inter-observer variation and to compare this against previously published datasets.

Methods

A technique of 'biopsying' the image to minimise inclusion of non-parenchymal tissues was developed. Additionally, thresholding was applied to exclude both pancreatic ducts and intrusions of visceral fat, with pixels of fat values of <1% or >20% being excluded. The new MR image 'biopsy' (MR-opsy) was compared to the standard method by 6 independent observers with wide experience of image analysis but

SUBMITTER: Al-Mrabeh A 

PROVIDER: S-EPMC5378354 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature