Cathepsin L in tumor angiogenesis and its therapeutic intervention by the small molecule inhibitor KGP94.

ABSTRACT: A significant proportion of breast cancer patients harbor clinically undetectable micrometastases at the time of diagnosis. If left untreated, these micro-metastases may lead to disease relapse and possibly death. Hence, there is significant interest in the development of novel anti-metastatic agents that could also curb the growth of pre-established micrometastases. Like primary tumor, the growth of metastases also is driven by angiogenesis. Although the role of cysteine protease Cathepsin L (CTSL) in metastasis associated tumor cell functions such as migration and invasion is well recognized, its role in tumor angiogenesis remains less explored. The present study examines the contribution of CTSL to breast cancer angiogenesis and evaluates the anti-angiogenic efficacy of CTSL inhibitor K

SUBMITTER: Sudhan DR 

PROVIDER: S-EPMC5378387 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature