A Genome-Wide Association Study to Identify Single-Nucleotide Polymorphisms for Acute Kidney Injury.

ABSTRACT:

Rationale

Acute kidney injury is a common and severe complication of critical illness and cardiac surgery. Despite significant attempts at developing treatments, therapeutic advances to attenuate acute kidney injury and expedite recovery have largely failed.

Objectives

Identifying genetic loci associated with increased risk of acute kidney injury may reveal novel pathways for therapeutic development.

Methods

We conducted an exploratory genome-wide association study to identify single-nucleotide polymorphisms associated with genetic susceptibility to in-hospital acute kidney injury.

Measurements and main results

We genotyped 609,508 single-nucleotide polymorphisms and performed genotype imputation in 760 acute kidney injury cases and 669 controls. We then evalua

SUBMITTER: Zhao B 

PROVIDER: S-EPMC5378420 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature