Patterns of Gestational Weight Gain in Early Pregnancy and Risk of Gestational Diabetes Mellitus.

ABSTRACT:

Background

Despite a call to study the effect of weight gain pattern on development of gestational diabetes mellitus, few studies have correctly adjusted for independent effects of gain after the first trimester. We used a conditional percentile approach to model the independent association between first and second trimester weight gain trajectories and development of gestational diabetes.

Methods

We sampled women delivering singleton infants from 1998 to 2010 at Magee-Womens Hospital in Pittsburgh, PA, (n = 124,590) using a case-cohort design. We modeled weight gain trajectories in the first and second trimesters of pregnancy using conditional weight gain percentiles, and used multivariable logistic regression to assess independent associations of the trajectory with gestat

SUBMITTER: MacDonald SC 

PROVIDER: S-EPMC5378599 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature