IL-3 up-regulates and activates human eosinophil CD32 and αMβ2 integrin causing degranulation.

ABSTRACT:

Background

Eosinophils contribute to the pathogenesis of multiple diseases, including asthma. Treatment with antibodies targeting IL-5 or IL-5 receptor α reduces the frequency of asthma exacerbations. Eosinophil receptors for IL-5 share a common ß-chain with IL-3 and GM-CSF receptors. We recently reported that IL-3 is more potent than IL-5 or GM-CSF in maintaining the ERK/p90S6K/RPS6 ribosome-directed signaling pathway, leading to increased protein translation.

Objective

We aimed to determine disease-relevant consequences of prolonged eosinophil stimulation with IL-3.

Results

Human blood eosinophils were used to establish the impact of activation with IL-3 on IgG-driven eosinophil degranulation. When compared to IL-5, continuing exposure to IL-3 further induced degran

SUBMITTER: Esnault S 

PROVIDER: S-EPMC5378663 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature