Early postoperative tumor progression predicts clinical outcome in glioblastoma-implication for clinical trials.

ABSTRACT: Molecular markers define the diagnosis of glioblastoma in the new WHO classification of 2016, challenging neuro-oncology centers to provide timely treatment initiation. The aim of this study was to determine whether a time delay to treatment initiation was accompanied by signs of early tumor progression in an MRI before the start of radiotherapy, and, if so, whether this influences the survival of glioblastoma patients. Images from 61 patients with early post-surgery MRI and a second MRI just before the start of radiotherapy were examined retrospectively for signs of early tumor progression. Survival information was analyzed using the Kaplan-Meier method, and a Cox multivariate analysis was performed to identify independent variables for survival prediction. 59 percent of patients showed s

SUBMITTER: Merkel A 

PROVIDER: S-EPMC5378726 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature