Intracrine androgen biosynthesis in renal cell carcinoma.

ABSTRACT:

Background

Renal cell carcinoma (RCC) is one of the most lethal genitourinary cancers. The presence of androgen receptor (AR) in RCC has recently been shown to be associated with higher tumour stage irrespective of gender. Because the clinical context of androgens in female RCC patients is similar to that of prostate cancer patients undergoing androgen-deprivation therapy, mechanisms underlying the emergence of castration-resistant prostate cancer (CRPC) may be at play in AR-positive RCC cells. Therefore, we hypothesized that AR-positive RCC has intratumoral steroidogenesis and that anti-androgen therapy may result in tumour suppression.

Methods

Mice were injected with an AR-positive RCC cell line. When tumours became palpable, surgical castration was performed and tumour vo

SUBMITTER: Lee GT 

PROVIDER: S-EPMC5379152 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature