Lack of spontaneous age-related brain pathology in Octodon degus: a reappraisal of the model.

ABSTRACT: Neurodegenerative diseases are characterized by the degeneration of specific brain areas associated with accumulation of disease-related protein in extra- or intra-cellular deposits. Their preclinical investigations are mostly based on genetically-engineered animals. Despite their interest, these models are often based on high level of disease-related protein expression, thus questioning their relevance to human pathology and calling for the alternate use of ecological models. In the past few years, Octodon degus has emerged as a promising animal model displaying age-dependent Alzheimer's disease-related pathology. As neurodegenerative-related proteins often co-deposit in the brain of patients, we assessed the occurrence of α-synuclein-related pathology in this model using state-of-the-art

SUBMITTER: Bourdenx M 

PROVIDER: S-EPMC5379186 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature