Day-and-night glycaemic control with closed-loop insulin delivery versus conventional insulin pump therapy in free-living adults with well controlled type 1 diabetes: an open-label, randomised, crossover study.

ABSTRACT:

Background

Tight control of blood glucose concentration in people with type 1 diabetes predisposes to hypoglycaemia. We aimed to investigate whether day-and-night hybrid closed-loop insulin delivery can improve glucose control while alleviating the risk of hypoglycaemia in adults with HbA_1c below 7·5% (58 mmol/mol).

Methods

In this open-label, randomised, crossover study, we recruited adults (aged ≥18 years) with type 1 diabetes and HbA_1c below 7·5% from Addenbrooke's Hospital (Cambridge, UK) and Medical University of Graz (Graz, Austria). After a 2-4 week run-in period, participants were randomly assigned (1:1), using web-based randomly permuted blocks of four, to receive insulin via the day-and-night hybrid closed-loop system or usual pump therapy for

SUBMITTER: Bally L 

PROVIDER: S-EPMC5379244 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature