Acute effects of focused ultrasound-induced increases in blood-brain barrier permeability on rat microvascular transcriptome.

ABSTRACT: Therapeutic treatment options for central nervous system diseases are greatly limited by the blood-brain barrier (BBB). Focused ultrasound (FUS), in conjunction with circulating microbubbles, can be used to induce a targeted and transient increase in BBB permeability, providing a unique approach for the delivery of drugs from the systemic circulation into the brain. While preclinical research has demonstrated the utility of FUS, there remains a large gap in our knowledge regarding the impact of sonication on BBB gene expression. This work is focused on investigating the transcriptional changes in dorsal hippocampal rat microvessels in the acute stages following sonication. Microarray analysis of microvessels was performed at 6 and 24 hrs post-FUS. Expression changes in individual genes and

SUBMITTER: McMahon D 

PROVIDER: S-EPMC5379491 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature