A comparative analysis of the foamy and ortho virus capsid structures reveals an ancient domain duplication.

ABSTRACT:

Background

The Spumaretrovirinae (foamy viruses) and the Orthoretrovirinae (e.g. HIV) share many similarities both in genome structure and the sequences of the core viral encoded proteins, such as the aspartyl protease and reverse transcriptase. Similarity in the gag region of the genome is less obvious at the sequence level but has been illuminated by the recent solution of the foamy virus capsid (CA) structure. This revealed a clear structural similarity to the orthoretrovirus capsids but with marked differences that left uncertainty in the relationship between the two domains that comprise the structure.

Methods

We have applied protein structure comparison methods in order to try and resolve this ambiguous relationship. These included both the DALI method and the SAP meth

SUBMITTER: Taylor WR 

PROVIDER: S-EPMC5379526 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature