Let-7e sensitizes epithelial ovarian cancer to cisplatin through repressing DNA double strand break repair.

ABSTRACT:

Background

Resistance to platinum-based chemotherapy remains a great challenge for ovarian cancer treatment. The human let-7 family contains 13 members located on nine different chromosomes, and most members have been implicated in the modulation of drug sensitivity in cancers. Our previous study showed that deregulation of let-7e in epithelial ovarian cancer (EOC) promoted the development of resistance to cisplatin. In the present study, we aimed to investigate the underlying mechanism and further evaluate the clinical value of let-7e in predicting chemo-response and prognosis in EOC.

Results

In situ hybridization assays revealed a significantly decreased expression of let-7e in chemo-resistant EOC tissues compared with chemo-sensitive cases. Transfection with let-7e agomir

SUBMITTER: Xiao M 

PROVIDER: S-EPMC5379542 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature