Prediction of reversible disulfide based on features from local structural signatures.

ABSTRACT:

Background

Disulfide bonds are traditionally considered to play only structural roles. In recent years, increasing evidence suggests that the disulfide proteome is made up of structural disulfides and reversible disulfides. Unlike structural disulfides, reversible disulfides are usually of important functional roles and may serve as redox switches. Interestingly, only specific disulfide bonds are reversible while others are not. However, whether reversible disulfides can be predicted based on structural information remains largely unknown.

Methods

In this study, two datasets with both types of disulfides were compiled using independent approaches. By comparison of various features extracted from the local structural signatures, we identified several features that differ sig

SUBMITTER: Sun MA 

PROVIDER: S-EPMC5379614 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature