A novel model fitted to multiple life stages of malaria for assessing efficacy of transmission-blocking interventions.

ABSTRACT:

Background

Transmission-blocking interventions (TBIs) aim to eliminate malaria by reducing transmission of the parasite between the host and the invertebrate vector. TBIs include transmission-blocking drugs and vaccines that, when given to humans, are taken up by mosquitoes and inhibit parasitic development within the vector. Accurate methodologies are key to assess TBI efficacy to ensure that only the most potent candidates progress to expensive and time-consuming clinical trials. Measuring intervention efficacy can be problematic because there is substantial variation in the number of parasites in both the host and vector populations, which can impact transmission even in laboratory settings.

Methods

A statistically robust empirical method is introduced for estimating inte

SUBMITTER: Sherrard-Smith E 

PROVIDER: S-EPMC5379616 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature