The c-Jun N-terminal kinase prevents oxidative stress induced by UV and thermal stresses in corals and human cells.

ABSTRACT: Coral reefs are of major ecological and socio-economic interest. They are threatened by global warming and natural pressures such as solar ultraviolet radiation. While great efforts have been made to understand the physiological response of corals to these stresses, the signalling pathways involved in the immediate cellular response exhibited by corals remain largely unknown. Here, we demonstrate that c-Jun N-terminal kinase (JNK) activation is involved in the early response of corals to thermal and UV stress. Furthermore, we found that JNK activity is required to repress stress-induced reactive oxygen species (ROS) accumulation in both the coral Stylophora pistillata and human skin cells. We also show that inhibiting JNK activation under stress conditions leads to ROS accumulation, subseq

SUBMITTER: Courtial L 

PROVIDER: S-EPMC5379690 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature