Nephrotoxicity-induced proteinuria increases biomarker diagnostic thresholds in acute kidney injury.

ABSTRACT:

Background

Paraquat ingestion is frequently fatal. While biomarkers of kidney damage increase during paraquat-induced acute kidney injury (AKI), significant concurrent proteinuria may alter diagnostic thresholds for diagnosis and prognosis to an unknown extent. This study evaluated the effect of albuminuria on biomarker cutoffs for diagnosis and outcome prediction.

Methods

This was a multi-centre prospective clinical study of patients following acute paraquat self-poisoning in 5 Sri Lankan hospitals. Biomarker concentrations were quantified using ELISA and microbead assays and correlated with urinary albumin. Functional-AKI was defined by the Acute Kidney Injury Network serum creatinine definition and alternatively by a ≥50% increase in serum cystatin C. Albuminuria was defi

SUBMITTER: Mohamed F 

PROVIDER: S-EPMC5379711 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature