Disrupted prediction errors index social deficits in autism spectrum disorder.

ABSTRACT: Social deficits are a core symptom of autism spectrum disorder; however, the perturbed neural mechanisms underpinning these deficits remain unclear. It has been suggested that social prediction errors-coding discrepancies between the predicted and actual outcome of another's decisions-might play a crucial role in processing social information. While the gyral surface of the anterior cingulate cortex signalled social prediction errors in typically developing individuals, this crucial social signal was altered in individuals with autism spectrum disorder. Importantly, the degree to which social prediction error signalling was aberrant correlated with diagnostic measures of social deficits. Effective connectivity analyses further revealed that, in typically developing individuals but not in a

SUBMITTER: Balsters JH 

PROVIDER: S-EPMC5379861 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature