The MICOS component Mic60 displays a conserved membrane-bending activity that is necessary for normal cristae morphology.

ABSTRACT: The inner membrane (IM) of mitochondria displays an intricate, highly folded architecture and can be divided into two domains: the inner boundary membrane adjacent to the outer membrane and invaginations toward the matrix, called cristae. Both domains are connected by narrow, tubular membrane segments called cristae junctions (CJs). The formation and maintenance of CJs is of vital importance for the organization of the mitochondrial IM and for mitochondrial and cellular physiology. The multisubunit mitochondrial contact site and cristae organizing system (MICOS) was found to be a major factor in CJ formation. In this study, we show that the MICOS core component Mic60 actively bends membranes and, when inserted into prokaryotic membranes, induces the formation of cristae-like plasma membran

SUBMITTER: Tarasenko D 

PROVIDER: S-EPMC5379949 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature