Host immunity to Plasmodium falciparum and the assessment of emerging artemisinin resistance in a multinational cohort.

ABSTRACT: Artemisinin-resistant falciparum malaria, defined by a slow-clearance phenotype and the presence of kelch13 mutants, has emerged in the Greater Mekong Subregion. Naturally acquired immunity to malaria clears parasites independent of antimalarial drugs. We hypothesized that between- and within-population variations in host immunity influence parasite clearance after artemisinin treatment and the interpretation of emerging artemisinin resistance. Antibodies specific to 12 Plasmodium falciparum sporozoite and blood-stage antigens were determined in 959 patients (from 11 sites in Southeast Asia) participating in a multinational cohort study assessing parasite clearance half-life (PCt_1/2) after artesunate treatment and kelch13 mutations. Linear mixed-effects mode

SUBMITTER: Ataide R 

PROVIDER: S-EPMC5380044 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature