Patterns of coordinated cortical remodeling during adolescence and their associations with functional specialization and evolutionary expansion.

ABSTRACT: During adolescence, the human cortex undergoes substantial remodeling to support a rapid expansion of behavioral repertoire. Accurately quantifying these changes is a prerequisite for understanding normal brain development, as well as the neuropsychiatric disorders that emerge in this vulnerable period. Past accounts have demonstrated substantial regional heterogeneity in patterns of brain development, but frequently have been limited by small samples and analytics that do not evaluate complex multivariate imaging patterns. Capitalizing on recent advances in multivariate analysis methods, we used nonnegative matrix factorization (NMF) to uncover coordinated patterns of cortical development in a sample of 934 youths ages 8-20, who completed structural neuroimaging as part of the Philadelphi

SUBMITTER: Sotiras A 

PROVIDER: S-EPMC5380071 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature