New insight on antimicrobial therapy adjustment strategies for gram-negative bacterial infection: A cohort study.

ABSTRACT: Gram-negative bacterial infections, especially multidrug-resistant (MDR) bacterial infection, are becoming a serious threat to public health. Although it is widely accepted that both appropriate initial empirical therapy and targeted therapy are important, but for patients needing therapy adjustment, few studies have explored whether adjustment strategy based on microbiologic susceptibility test (MST) brings better outcome compared with empirical adjustment.A total of 320 patients with gram-negative bacterial infection (airway, blood, or pleural effusion) were selected and a prospective cohort study was conducted. Baseline characteristics and outcomes (microbiologic, clinical, and economic) were documented during follow-up.MDR and nosocomial infections were common among subjects. Initial t

SUBMITTER: Du W 

PROVIDER: S-EPMC5380256 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature