Multiple Organ Dysfunction in Children Mechanically Ventilated for Acute Respiratory Failure.

ABSTRACT:

Objectives

The impact of extrapulmonary organ dysfunction, independent from sepsis and lung injury severity, on outcomes in pediatric acute respiratory failure is unclear. We sought to determine the frequency, timing, and risk factors for extrapulmonary organ dysfunction and the independent association of multiple organ dysfunction syndrome with outcomes in pediatric acute respiratory failure.

Design

Secondary observational analysis of the Randomized Evaluation of Sedation Titration for Respiratory Failure cluster-randomized prospective clinical trial conducted between 2009 and 2013.

Setting

Thirty-one academic PICUs in the United States.

Patients

Two thousand four hundred forty-nine children mechanically ventilated for acute respiratory failure enrolled in Ran

SUBMITTER: Weiss SL 

PROVIDER: S-EPMC5380520 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature