Cooperation of Gastric Mononuclear Phagocytes with Helicobacter pylori during Colonization.

ABSTRACT: Helicobacter pylori, the dominant member of the human gastric microbiota, elicits immunoregulatory responses implicated in protective versus pathological outcomes. To evaluate the role of macrophages during infection, we employed a system with a shifted proinflammatory macrophage phenotype by deleting PPARγ in myeloid cells and found a 5- to 10-fold decrease in gastric bacterial loads. Higher levels of colonization in wild-type mice were associated with increased presence of mononuclear phagocytes and in particular with the accumulation of CD11b⁺F4/80^hiCD64⁺CX₃CR1⁺ macrophages in the gastric lamina propria. Depletion of phagocytic cells by clodronate liposomes in wild-type mice resulted in a reduction of gastric H. pylori

SUBMITTER: Viladomiu M 

PROVIDER: S-EPMC5380565 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature