Genetic Risk Prediction of Atrial Fibrillation.

ABSTRACT:

Background

Atrial fibrillation (AF) has a substantial genetic basis. Identification of individuals at greatest AF risk could minimize the incidence of cardioembolic stroke.

Methods

To determine whether genetic data can stratify risk for development of AF, we examined associations between AF genetic risk scores and incident AF in 5 prospective studies comprising 18 919 individuals of European ancestry. We examined associations between AF genetic risk scores and ischemic stroke in a separate study of 509 ischemic stroke cases (202 cardioembolic [40%]) and 3028 referents. Scores were based on 11 to 719 common variants (≥5%) associated with AF at P values ranging from <1×10^-3 to <1×10^-8 in a prior independent genetic association study.

Results

SUBMITTER: Lubitz SA 

PROVIDER: S-EPMC5380586 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature