The Transcriptome of Leishmania major Developmental Stages in Their Natural Sand Fly Vector.

ABSTRACT: The life cycle of the Leishmania parasite in the sand fly vector involves differentiation into several distinctive forms, each thought to represent an adaptation to specific microenvironments in the midgut of the fly. Based on transcriptome sequencing (RNA-Seq) results, we describe the first high-resolution analysis of the transcriptome dynamics of four distinct stages of Leishmania major as they develop in a natural vector, Phlebotomus duboscqi The early transformation from tissue amastigotes to procyclic promastigotes in the blood-fed midgut was accompanied by the greatest number of differentially expressed genes, including the downregulation of amastins, and upregulation of multiple cell surface proteins, sugar and amino acid transporters, and genes related to gluco

SUBMITTER: Inbar E 

PROVIDER: S-EPMC5380837 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature