Rhodium(i)-catalyzed stereoselective [4+2] cycloaddition of oxetanols with alkynes through C(sp³)-C(sp³) bond cleavage.

ABSTRACT: An efficient and convenient synthesis of highly functionalized dihydropyrans has been achieved through rhodium(i)-catalysed tandem C(sp³)-C(sp³) bond cleavage and annulation of oxetanols with alkynes. An enantioselective version was enabled using a Binaphine ligand. Excellent site-selectivity and remarkable enantioretention are obtained for 2-substituted oxetanols.

SUBMITTER: Guo R 

PROVIDER: S-EPMC5380880 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature