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Activation of perineuronal net-expressing excitatory neurons during associative memory encoding and retrieval.

ABSTRACT: Perineuronal nets (PNNs), proteoglycan-rich extracellular matrix structures, are thought to be expressed around inhibitory neurons and contribute to critical periods of brain function and synaptic plasticity. However, in some specific brain regions such as the amygdala, PNNs were predominantly expressed around excitatory neurons. These neurons were recruited during auditory fear conditioning and memory retrieval. Indeed, the activation of PNN-expressing excitatory neurons predicted cognitive performance.

SUBMITTER: Morikawa S

PROVIDER: S-EPMC5380958 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Activation of perineuronal net-expressing excitatory neurons during associative memory encoding and retrieval.

Morikawa Shota S Ikegaya Yuji Y Narita Minoru M Tamura Hideki H

Scientific reports 20170405

Perineuronal nets (PNNs), proteoglycan-rich extracellular matrix structures, are thought to be expressed around inhibitory neurons and contribute to critical periods of brain function and synaptic plasticity. However, in some specific brain regions such as the amygdala, PNNs were predominantly expressed around excitatory neurons. These neurons were recruited during auditory fear conditioning and memory retrieval. Indeed, the activation of PNN-expressing excitatory neurons predicted cognitive per ...[more]

PMID: 28378772

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