Glucose and lipoprotein biomarkers and breast cancer severity using data from the Swedish AMORIS cohort.

ABSTRACT:

Background

The lipid and glucose metabolisms are postulated as possible intermediary mechanisms in linking obesity and breast cancer (BC). Links between serum lipid and glucose biomarkers and BC risk has been observed in the Swedish Apolipoprotein MORtality RISk (AMORIS) cohort. We conducted a follow-up analysis including information on tumour characteristics.

Methods

One thousand eight hundred twenty-four women diagnosed with BC, with serum biomarker levels of glucose, triglycerides, cholesterol (total, HDL, and LDL), and apolipoproteins A-1 and B recorded in a routine health check at baseline were included. BC severity was split into categories (good, moderate, and poor prognosis) based on ER status, TNM stage, and age at diagnosis. Proportional odds models were used to ob

SUBMITTER: Melvin JC 

PROVIDER: S-EPMC5381045 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature