Association of gene coding variation and resting metabolic rate in a multi-ethnic sample of children and adults.

ABSTRACT:

Background

Resting metabolic rates (RMR) vary across individuals. Understanding the determinants of RMR could provide biological insight into obesity and its metabolic consequences such as type 2 diabetes and cardiovascular diseases.

Methods

The present study measured RMR using reference standard indirect calorimetry and evaluated genetic variations from an exome array in a sample of children and adults (N = 262) predominantly of African and European ancestry with a wide range of ages (10 - 67 years old) and body mass indices (BMI; 16.9 - 56.3 kg/m² for adults, 15.1 - 40.6 kg/m2 for children).

Results

Single variant analysis for RMR identified suggestive loci on chromosomes 15 (rs74010762, TRPM1, p-value = 2.7 × 10-6), 1 (rs2358728 and

SUBMITTER: Hellwege JN 

PROVIDER: S-EPMC5381071 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature