Preclinical Melanoma Imaging with ⁶⁸Ga-Labeled α-Melanocyte-Stimulating Hormone Derivatives Using PET.

ABSTRACT: It is estimated that melanoma accounted for 76,380 new cases and 10,130 deaths in the United States in 2016. The melanocortin 1 receptor (MC1R) is highly expressed in the vast majority of melanomas, which makes it an attractive target for molecular imaging and radionuclide therapy. Lactam bridge-cyclized α-melanocyte-stimulating hormone (Ac-Nle⁴-cyclo[Asp⁵-His-D-Phe⁷-Arg-Trp-Lys¹⁰]-NH₂, or Nle-CycMSH_hex) analogues have been successfully developed and studied for MC1R-targeted imaging, predominantly with single-photon emission computed tomography (SPECT). The goal of this study was to design and evaluate novel peptides for melanoma imaging with positron emission tomography (PET). We designed and synthesized three peptides, DO

SUBMITTER: Zhang C 

PROVIDER: S-EPMC5381245 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature