Dietary pattern, inflammation and cognitive decline: The Whitehall II prospective cohort study.

ABSTRACT:

Background & aims

Low-grade inflammation appears to play an etiological role in cognitive decline. However the association between an inflammatory dietary pattern and cognitive decline has not been investigated. We aimed to investigate dietary patterns associated with inflammation and whether such diet is associated with cognitive decline.

Methods

We analyzed 5083 participants (28.7% women) from the Whitehall II cohort study. Diet and serum interleukin-6 (IL-6) were assessed in 1991-1993 and 1997-1999. We used reduced rank regression methods to determine a dietary pattern associated with elevated IL-6. Cognitive tests were performed in 1997-1999 and repeated in 2002-2004 and 2007-2009. The association between dietary pattern and cognitive decline between ages 45 and 79 was a

SUBMITTER: Ozawa M 

PROVIDER: S-EPMC5381339 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature