Detection of Atherosclerotic Inflammation by ⁶⁸Ga-DOTATATE PET Compared to [¹⁸F]FDG PET Imaging.

ABSTRACT:

Background

Inflammation drives atherosclerotic plaque rupture. Although inflammation can be measured using fluorine-18-labeled fluorodeoxyglucose positron emission tomography ([¹⁸F]FDG PET), [¹⁸F]FDG lacks cell specificity, and coronary imaging is unreliable because of myocardial spillover.

Objectives

This study tested the efficacy of gallium-68-labeled DOTATATE (⁶⁸Ga-DOTATATE), a somatostatin receptor subtype-2 (SST₂)-binding PET tracer, for imaging atherosclerotic inflammation.

Methods

We confirmed ⁶⁸Ga-DOTATATE binding in macrophages and excised carotid plaques. ⁶⁸Ga-DOTATATE PET imaging was compared to [¹⁸F]FDG PET imaging in 42 patients with atherosclerosis.

Results

Target SSTR2 g

SUBMITTER: Tarkin JM 

PROVIDER: S-EPMC5381358 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature