Protein corona composition of superparamagnetic iron oxide nanoparticles with various physico-chemical properties and coatings.

ABSTRACT: Because of their biocompatibility and unique magnetic properties, superparamagnetic iron oxide nanoparticles NPs (SPIONs) are recognized as some of the most prominent agents for theranostic applications. Thus, understanding the interaction of SPIONs with biological systems is important for their safe design and efficient applications. In this study, SPIONs were coated with 2 different polymers: polyvinyl alcohol polymer (PVA) and dextran. The obtained NPs with different surface charges (positive, neutral, and negative) were used as a model study of the effect of surface charges and surface polymer materials on protein adsorption using a magnetic separator. We found that the PVA-coated SPIONs with negative and neutral surface charge adsorbed more serum proteins than the dextran-coated SPION

SUBMITTER: Sakulkhu U 

PROVIDER: S-EPMC5381372 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature