Pulse pressure-dependent cerebrovascular eNOS regulation in mice.

ABSTRACT: Arterial blood pressure is oscillatory; whether pulse pressure (PP) regulates cerebral artery myogenic tone (MT) and endothelial function is currently unknown. To test the impact of PP on MT and dilation to flow (FMD) or to acetylcholine (Ach), isolated pressurized mouse posterior cerebral arteries were subjected to either static pressure (SP) or a physiological PP (amplitude: 30 mm Hg; frequency: 550 bpm). Under PP, MT was significantly higher than in SP conditions ( p < 0.05) and was not affected by eNOS inhibition. In contrast, under SP, eNOS inhibition increased ( p < 0.05) MT to levels observed under PP, suggesting that PP may inhibit eNOS. At a shear stress of 20 dyn/cm², FMD was lower ( p < 0.05) under SP than PP. Under SP, eNOS-dependent [Formula: see text] production co

SUBMITTER: Raignault A 

PROVIDER: S-EPMC5381440 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature