Cerebral 5-HT release correlates with [¹¹C]Cimbi36 PET measures of 5-HT2A receptor occupancy in the pig brain.

ABSTRACT: Positron emission tomography (PET) can, when used with appropriate radioligands, non-invasively generate temporal and spatial information about acute changes in brain neurotransmitter systems. We for the first time evaluate the novel 5-HT_2A receptor agonist PET radioligand, [¹¹C]Cimbi-36, for its sensitivity to detect changes in endogenous cerebral 5-HT levels, as induced by different pharmacological challenges. To enable a direct translation of PET imaging data to changes in brain 5-HT levels, we calibrated the [¹¹C]Cimbi-36 PET signal in the pig brain by simultaneous measurements of extracellular 5-HT levels with microdialysis and [¹¹C]Cimbi-36 PET after various acute interventions (saline, citalopram, citalopram + pindolol, fenfluramine). In a

SUBMITTER: Jorgensen LM 

PROVIDER: S-EPMC5381441 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature